Highlights of exciting immunoSEQ® Data at AACR 2021

Highlights of exciting immunoSEQ Data at AACR 2021
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    This year’s American Association of Cancer Research (AACR) Annual Meeting, held virtually in April, highlighted exciting research taking place across the cancer research landscape. Below are several key trends and research findings from this year’s meeting:

    • COVID-19 & Cancer
      • SARS-CoV-2 and KSHV: Findings from Zhiqiang Qin et al. from the University of Arkansas for Medical Sciences, Little Rock, AR, USA’s study showed that SARS-CoV-2 proteins and anti-COVID-19 drugs could induce lytic reactivation of Kaposi’s sarcoma-associated herpesvirus (KSHV) and that there was upregulation of ACE2 in AIDS-KS tissues. These observations indicate that KSHV may increase the risk of SARS-CoV-2 and that SARS-CoV-2 may increase the risk of KSHV-associated cancers.
    • Anti-cancer effect mediated by T-cell response
      • T-cell responses are more potent in CIS costimulation. Itziar Otano et al. from CIMA-University of Navarra, Pamplona, Spain presented a study comparing CD137 costimulation in-cis and in-trans with regard to the TCR-CD3-ligating cells. CD137 costimulation in-cis was far superior in terms of T-cell activation, proliferation, and survival, NF-κB signaling, and induction of cell-cycle and DNA damage repair gene expression.
    • Adoptive cell therapy in immuno-oncology research
      • A study conducted by Miles H. Linde et al. from Stanford University, Stanford, CA, USA established a novel cancer vaccination approach utilizing myeloid lineage reprogramming to directly convert cancer cells into tumor reprogramed-APCs (TR-APCs) with broad implications for clinical immuno-oncology. They observed that in vivo immunological response to TR-APC induction revealed oligoclonal T cell expansion and establishment of cancer-specific immunological memory and in vivo TR-APC induction elicits modest extension to overall survival in immunodeficient hosts.
    • CAR-T Therapy Continues to Grab Attention
      • Yufei Wang et al. from Dana-Farber Cancer Institute, Boston, MA, USA reported preclinical data of anti-CD70/CAIX dual-targeting fine-tuned immune restoring (DFIR) CAR-T cells designed to target clear cell renal cell carcinoma (ccRCC) tumor cells without on-target off-tumor side effects. The DFIR-CAR T cells secreted immune checkpoint inhibitor (ICI) monoclonal antibodies at the tumor site and exhibited superior efficacy and safety profiling.
    • Engineered T-cell constructs – Quite the buzz
      • Amorette Barber et al. from Longwood University, Farmville, VA, USA presented on using gamma delta T cells derived from healthy donors and engineered with a chimeric PD-1 receptor (chPD1-gdT cells) to target PDL-1+ tumor cells. chPD1-gdT cells selectively killed PDL-1+ tumor cells with minimal on-target/off-tumor toxicities and without off-target toxicities and will be further assessed in phase I/II clinical trials.

    Adaptive Biotechnologies Exhibitor Theater at AACR

    Adaptive Biotechnologies’ immunoSEQ® Technology is an end-to-end immunosequencing solution capable of profiling millions of B- and T-cell receptors at high throughput and providing a quantitative view into the immune repertoire.

    Presentation: Utilizing immunosequencing in Cancer Research and Drug Discovery

    Watch our Exhibitor Spotlight presentation titled, Utilizing Immunosequencing in Cancer Research and Drug Discovery, presented by Dr. Patrick Raber, PhD, and Dr. Adria Carbo to learn about:

    • The principles behind the immunoSEQ Technology
    • Key use cases of the immunoSEQ Technology in oncology research
    • Applications in pre-clinical and clinical research settings
    • An overview of Adaptive’s drug development capabilities, including identifying and characterizing viable therapeutic targets in solid tumors.

    WATCH NOW – Utilizing Immunosequencing in Cancer Research & Drug Discovery

    immunoSEQ Customer Posters

    Explore this subset of posters and presentations demonstrating how immune repertoire profiling with the immunoSEQ Assays is advancing cancer research. New data will demonstrate how immunosequencing at scale and with precision using Adaptive’s immunoSEQ Assay may be used in research to track overall survival and response to novel immmunotherapies, such as checkpoint inhibitors and cancer vaccines, in solid tumors.

    T-cell abundance, clonality and disease specific survival in colorectal cancer

    Presented by: Joseph Bonner, City of Hope National Medical Center
    Session: Infection and Immune Factors Poster Session
    Abstract

    Germline genetic regulation of the adaptive immune response in colorectal cancer

    Presented by: Stephanie L. Schmit, Cleveland Clinic
    Session: Genome-Wide Association Studies (GWAS) / Post-GWAS Poster Session
    Abstract

    Clinical and epidemiologic predictors of clonal immune responses in colorectal cancer

    Presented by: Stephen B. Gruber City of Hope National Medical Center
    Session: Immune Cells in the Tumor Microenvironment Poster Session
    Abstract

    You can view our full collection of 600+ publications to learn more about how researchers around the world are using the gold-standard of immunosequencing to drive their discoveries.
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    If you would like to learn more about how the immunoSEQ Technology can help you propel your research, contact us today!

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